Hoffmann-la Roche Inc.

Eberhard-karls-universitaet Tuebingen Universitaetsklinikum

Eberhard-Karls-Universität Tuebingen Universitaetsklinikum

Eberhard-karls-universitat Tubingen

Reiner Lammers

Hans-Joerg Buehring

Hans-Jorg Buhring

Sabrina Treml

Selim Kuci

Tim Conze

Georg Fertig

Birgit Bossenmaier

Hans-Willi Krell

Gerhard Niederfellner

Alexander Lifke

Wichard Vogel

Venkata Lokesh Battula

Hans-Jörg Bühring

The present invention relates to a method for isolating and/or identifying stem cells having adipocytic, chondrocytic and pancreatic differentiation potential, wherein an antibody is used that binds to the antigen TNAP, alone or in combination with an antibody that binds to the cell surface antigen CD56. The invention also relates to stem cells isolated by the method according to the invention for treating defects or damages or diseases in bone or cartilage of a patient in need thereof.

Isolation and/or identification of stem cells having adipocytic, chondrocytic and pancreatic differentiation potential

The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.

Antibodies against CDCP1 for the treatment of cancer

The present invention concerns antibodies produced from hybridoma cell lines chosen from the group comprising W8B2, W1C3, W7C6, W5C4, 24D2, 28D4, HEK-3D6, W4A5, W3D5, W5C5, 9A3G9, 58B1, F9-3C2F1, 39D5, for isolating and/or identifying homogenous mesenchymal stem cells. Furthermore a method is presented with which mesenchymal stem cells from adult primary tissue, for example bone marrow, can be identified and isolated with a high level of purity.

Method for isolating and/or identifying mesenchymal stem cells (MSC)

Monoclonal antibodies, or fragments thereof, are used for isolating and/or identifying at least one cell population. The cell population can include any of the following types of cells: haematopoietic stem cells, neuronal stem cells, neuronal progenitor cells, mesenchymal stem cells and mesenchymal progenitor cells. The antibodies, or fragments thereof, bind to an antigen which is the same as that bound by an antibody which is produced by the hybridoma cell lines CUB1, CUB2, CUB3 and CUB4, which were deposited in the DSMZ under the numbers DSM ACC2569, DSM ACC2566 and DSM ACC2565, on 14 Aug. 2002, and DSM ACC2551, on 12 Jul. 2002.

Antibodies for identifying and/or isolating at least one cell population

The invention relates to monoclonal antibodies, or fragments thereof, for isolating and/or identifying at least one cell population which is selected from the group comprising haematopoietic stem cells, neuronal stem cells, neuronal progenitor cells, mesenchymal stem cells and mesenchymal progenitor cells. The antibodies, or fragments thereof, bind to an antigen which is the same as that bound by an antibody which is produced by the hybridoma cell lines CUB1, CUB2, CUB3 and CUB4, which were deposited in the DSMZ under the numbers DSM ACC2569, DSM ACC2566 and DSM ACC2565, on Aug, 14, 2002, and DSM ACC2551, on Dec. 7, 2002.

Antibodies for identifying and/or isolating at least one cell population which is selected from the group comprising haematopoietic stem cells, neuronal stem cells, neuronal precursor cells, mesenchymal stem cells and mesenchymal precursor cells

The invention relates to a monoclonal antibody, or fragments thereof, for isolating and/or identifying mesenchymal stem cells. In this connection, the antibody, or fragments thereof, bind to an antigen which is the same as that bound to by an antibody which is produced by the hybridoma cell line W8B2, which was deposited on 14.08.2002 in the DSMZ [German collection of microorganisms and cell cultures] under the number DSM ACC2567.

Monoclonal antibody W8B2 and method of use

Growing community of inventors

Tuebingen, Germany

Reiner Lammers