Hoechst Aktiengesellschaft

Reiner Kirrstetter

Rudolf Lattrell

Walter Durckheimer

Wilfried Schwab

Gerhard Seibert

Gerd Fischer

Karl-Heinz Budt

Rolf Horlein

Walter Durokheimer

Compound I ##STR1## is obtained by reaction of compound II with compound III

Process for the preparation of penem compounds

Crystallized cephem-acid addition salts of the general formula ##STR1## pharmaceutical preparations which contain such cephem derivatives and are active against bacterial infections, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.

Crystallized cephem-acid addition salts, and a process for the

Process for the preparation of cephem compounds of the formula ##STR1## wherein R is optionally substituted aminothiazolyl or amino-1,2,4-thiadiazolyl, A is optionally substituted pyridinium, R.sup.1 is hydrogen or methoxy and R.sup.2 are special aliphatic substituents, by a nucleophilic replacement in the substituent in 3-position in the presence of tri-C.sub.1 C.sub.4 -alkyl iodosilane.

Process for the manufacture of 3-pyridinium-methyl-cephalosporins

Process for the preparation of cephem compounds of the formula ##STR1##

Process for the preparation of cephem compounds

The invention relates to cephem derivatives of the general formula I ##STR1## and their physiologically acceptable acid addition salts, to pharmaceutical formulations active against bacterial infections, to processes for preparing the compounds and formulations, and to the use of the compounds for combating bacterial infections.

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Kelkheim, Germany

Reiner Kirrstetter