Hoffmann-la Roche Inc.

Reiner Gentz

Manfred Brockhaus

Werner Lesslauer

Hansruedi Lotscher

Ernst-Jurgen Schlaeger

Erich Hochuli

Dietrich Stuber

Heinz Dobeli

Bernhard Eggimann

Dembic Zlatko

Zlatko Dembic

Ulrich Certa

Bela Takacs

The present invention is concerned with non-soluble proteins and soluble or insoluble fragments thereof, which bind TNF, in homogeneous form, as well as their physiologically compatible salts, especially those proteins having a molecular weight of about 55 or 75 kD (non-reducing SDS-PAGE conditions), a process for the isolation of such proteins, antibodies against such proteins, DNA sequences which code for non-soluble proteins and soluble or non-soluble fragments thereof, which bind TNF, as well as those which code for proteins comprising partly of a soluble fragment, which binds TNF, and partly of all domains except the first of the constant region of the heavy chain of human immunoglobulins and the recombinant proteins coded thereby as well as a process for their manufacture using transformed pro- and eukaryotic host cells.

Human TNF receptor

Human TNF receptor fusion protein

DNA encoding a human TNF binding protein

Fusion proteins and a process for their purification by means of metal chelate affinity chromatography on NTA resins are provided by this invention.

Affinity peptides

The present invention provides polypeptides having an amino acid sequence derived from the 190 kD precursor to the major merozoite surface antigens of the K1 isolate of Plasmodium falciparum. These polypeptides are capable of eliciting an immune response against different isolates of Plasmodium falciparum. The invention further provides immunogenic compositions and vaccines containing such polypeptides, antibodies raised against the polypeptides. a DNA sequence coding for one of the polypeptides, a replicable microbial vector containing such a DNA sequence and a microorganism transformed with such a vector. The invention also provides processes for the production of the polypeptides, immunogenic compositions, microorganisms and antibodies of the invention and for the use of the polypeptides and immunogenic compositions for the immunization of mammals against malaria.

Plasmodium falciparum merozoite antigen peptides

Growing community of inventors

Rheinfelden, Germany

Reiner Gentz