Novartis Ag

Regis Cebe

David Langdon Yowe

Fangmin Xu

Shari Lynn Caplan

Brian R Boettcher

John A Taraszka

Stephane Olland

Guochun Li

Darko Skegro

Brian Walter Granda

Connie Hong

Dattananda Chelur

Haihui Lu

Sebastien Irigaray

Amy Rayo

Sunyoung Jang

The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

CD19 binding molecules and uses thereof

The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human &#x3b2;-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

Methods of treating FGF21-associated disorders

The present disclosure relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human &#x3b2;-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

FGF21 mimetic antibodies and uses thereof

The present invention provides heterodimeric antibodies and fragments thereof and methods for their preparation, wherein the pairing of heavy and light chains has been improved. Interface residues were mutated such that each light chain strongly favoured its cognate heavy chain when two different heavy chains and two different light chains were co-transfected and co-expressed in the same cell to assemble a functional, heterodimeric antibody or fragment thereof.

Engineered heterodimeric proteins

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Saint-Louis, France

Regis Cebe