Ariad Pharmaceuticals, Inc.

Phoenicia Biosciences, Inc.

Regine Bohacek

William C Shakespeare

Tomi K Sawyer

Yihan Wang

Chester A Metcalf, Iii

Rajeswari Sundaramoorthi

Michael G Yang

Manfred Weigele

Charles Joseph Eyermann

David C Dalgarno

Susan Park Perrine

George P Luke

Craig S Takeuchi

Noriyuki H Kawahata

Karina Macek

Virginia A Jacobsen

Methods of treating blood disorders are described.

Methods for treating blood disorders

This invention relates to compounds of the general formula: in which R, R, Rand Rare as defined herein, and to their preparation and use.

Quinazolines and uses thereof

This invention relates to compounds of the general formula: in which R, R, Rand Rare as defined herein, and to their preparation and use. In these compounds, Ris an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety which comprises one or more phosphorus-containing moieties.

Purine derivatives

The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof):in which R, R, R, R, R, R, R, R, AK, p, q, r and X are as defined herein, and to their preparation and use.

Quinolinones and uses thereof

This invention relates to compounds of the general formula:in which R, R, Rand Rare as defined herein, and to their preparation and use.

Quinolines and uses thereof

This invention relates to compounds of the general formula:

Indolinones and uses thereof

Phenylamino-pyrimidines and uses thereof

This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutic compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of formula (1) as defined herein.

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Boston, MA, United States of America

Regine Bohacek