Allosource

Reginald L Stilwell

Adrian C Samaniego

Brent Lee Atkinson

Yaling Shi

Kenneth Blood

Jan Zajdowicz

Matthew Peterson

William Maslanik

Luke Shubin

Ramasamy Sakthivel

Lauren Blume

Cathleen Lucine Badillo

Timothy Bennett

Joslynn Shamis

Yurid Gourgel

Bruce Mock

Brian Dittman

Aidan Griffin

Charles Manuele

Carolyn Barrett Rorick

Arthur Joslyn

Mckenzie Pietrafeso

Madeleine Dahl

Matthew James Southard

Brent Atkinson

Marina Katelyn Bull

Kathryn Hanzlicek

Implant for pelvic organ prolapse

Systems and methods for the automated demineralization of bone and decellularization of soft tissue include a mixing assembly communicatively coupled with a control and reporting system. The mixing assembly includes a housing that supports a cannister sub-assembly forming a mixing chamber having a reagent inlet, a reagent outlet, and an internal fluid agitator. A motor is operably coupled with the agitator and configured to spin the agitator in first and second directions relative to the cannister, thereby agitating fluid contained within the mixing chamber. At least one pump is configured to progressively inject measured quantities of a plurality of reagents into the mixing chamber. The associated control and reporting system includes a user terminal that displays a graphical user interface enabling a user to initiate an automated demineralization or decellularization procedure in which the mixing assembly demineralizes tissue placed within the mixing chamber. Other embodiments are also disclosed.

Automated system and methods for tissue demineralization

The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

Cellular bone grafts, and methods of manufacture and use

The present invention provides compositions for treating soft tissue injuries comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix. Methods of making and using compositions comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix are also provided.

Cell repopulated collagen matrix for soft tissue repair and regeneration

Flowable matrix compositions and methods of their use and manufacture are provided. Exemplary compositions may include a flowable, syringeable, putty-like form of acellular human dermal matrix. In some cases, compositions may include a moldable acellular collagen extracellular matrix. In use, the matrix compositions can be used to fill or treat skin voids, channel wounds, and other soft tissue deficiencies.

Flowable matrix compositions and methods

Growing community of inventors

Parker, CO, United States of America

Reginald L Stilwell