Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Reginald Keith Avery

Bradley David Olsen

Gareth H McKinley

Alireza Khademhosseini

Akhilesh K Gaharwar

Matthew J Glassman

Elastin-like polypeptides (ELPs) form hydrogels upon heating. The polypeptides can comprise the generic sequence (XPAVG)(SEQ ID NO: 4), wherein independently for each occurrence X can be any one of a number of different natural or unnatural amino acids, and n is chosen to determine the size of the protein. Hydrogels comprising the polypeptides have mechanical properties, including elastic modulus and fracture toughness, required for load-bearing applications.

Thermoreversible hydrogels from the arrested phase separation of elastin-like polypeptides

Provided herein are hemostatic compositions useful for treating wounds in a patient in need thereof. An exemplary hemostatic comprises gelatin or a derivative thereof and silicate nanoparticles. Methods of use, kits comprising the compositions, and a process of making the compositions are also provided.

Nanocomposite hydrogels

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Bel Air, MD, United States of America

Reginald Keith Avery