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Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Belorussky Nauchno-issledovatelsky Institute Epidemiologii I

Regina Abramovna Zhuk

Solomon Aronovich Giller

Anna Eduardovna Berzinya

Aina A Zidermane

Marger J Lidaka

Vyacheslav A Rusyaev

Marite K Kilevitsa

Veniamin I Votyakov

Laima Avgustovna Sherinya

Marina A Madre

Olga I Starkova

Juris A Maurinsh

Marger J Lidak

Evgeny I Boreko

Olga T Andreeva

Ljudmila V Korobchenko

Ruta A Paegle

9-substituted guanines

1-(5-Fluoruacil-1)-2,5-di-O-acetyl-.beta.-D-glucofuranurono-6,3-lactone has the formula ##STR1## Said substance has a marked antiblastic action. The substance is less toxic compared with the known preparation of similar action.

1-(5-Fluoruracil-1)-2,5-di-O-acetyl-.beta.-D-glucofuranurono-6,3-lactone

A process for producing N.sub.1 -(.alpha.-butyrolactone)- and N.sub.1 -(.alpha.-valerolactone)-5-substituted uracils of the formula: ##SPC1## Wherein R.sub.1 is hydrogen, methyl, a trihalomethyl or a halogen; R.sub.2 is hydrogen or an alkyl, n = 1 or 2, characterized in that a bis(trimethylsilyl)-5-substituted uracil of the formula: ##SPC2## Wherein R.sub.1 is hydrogen, methyl, a trihalomethyl or a halogen, is treated with an .alpha.-bromolactone of the formula: ##SPC3## Wherein R.sub.2 is hydrogen or an alkyl, n = 1 or 2. The reaction is conducted at a temperature ranging from 80.degree. to 160.degree.C. From the reaction mixture thus obtained there is distilled off the resulting trimethylbromosilane formed during the reaction, and the reaction mixture is treated with a lower aliphatic alcohol.

Process for producing N.sub.1 -(.alpha.-butyrolactone- and N.sub.1 (.alpha.

A process for producing N.sub.1 -(dihydroxyalkyl)-5-substituted uracils of the formula: ##SPC1## Wherein

Process for producing N.sub.1 -(Dihydroxyalkyl)-5-substituted uracils

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Riga, undefined

Regina Abramovna Zhuk