The University of Arizona

Regan Memmott

Laurence H Hurley

Adam Siddiqui-Jain

Scot W Ebbinghaus

Among the different intrastrand quadruplex structures that can arise from duplex DNA, it has been discovered that the nucleotide sequences (GGA)(SEQ ID NO: 1) and (GGA)GG (SEQ ID NO: 2) form biologically significant quadruplex structures. Thus, provided herein are methods for identifying molecules that modulate the biological activity of quadruplex DNA comprising the nucleotide sequence (GGA)(SEQ ID NO: 1) or the nucleotide sequence (GGA)GG (SEQ ID NO: 2), and specifically, methods for identifying molecules that bind such quadruplexes. Also provided herein are methods for modulating the biological activity of a biologically significant native quadruplex DNA with a molecule identified by the methods described herein.

Growing community of inventors

Tucson, AZ, United States of America

Regan Memmott