Pharm-eco Laboratories, Inc.

Reem M Haider

Adel M Moussa

Minghua Sun

Richard John Lombardy

Jurjus Jurayj

Emile Al-Farhan

Weiheng Wang

Robert Stevenson

Milind P Sant

Ahmed Hilmy

Heather Taft

HaeSuk Suh

The present invention is a method of preparing a 3-aryl-1-indanamine represented by structural formula I:

Synthesis of 3-aryl-1-indanamines

Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz&lsqb;b,e&rsqb;azepines from a 2-aminobenzophenone represented by the following structural formula:

Synthesis of 11-aryl-5,6-dihydro-11H-dibenz&lsqb;b,e&rsqb;azepines

Disclosed is a method of preparing a compound represented by the following structural formula: ##STR1## and physiological salts thereof. R.sup.1 is --H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R.sup.2 is a substituted or unsubstituted 2-hydroxy-1-ethyl group. Ring A is a substituted or unsubstituted aryl group. Ring B is substituted or unsubstituted at position two. The method comprises reacting a substituted or unsubstituted aryl hydrazine or salt derived from a substituted or unsubstituted aryl hydrazine with a compound represented by the following structural formula: ##STR2##

Method for making substituted indoles

Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula: ##STR1## and a starting material represented by the following structural formula: ##STR2## Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsubstituted or substituted with one, two or three substituents. Each substituent on Phenyl Ring A, Phenyl Ring B and Phenyl Ring C is independently chosen. R is --H, a aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, --C(O)--R', --C(O)--H, --C(O)--NHR', --S(O).sub.2 R', --C(O)--C(O)--R', --C(O)--C(O)--H, --C(S)--R', --C(S)--H, --C(O)--OR', --C(S)--OR', --C(O)--SR', --C(S)--SR', --C(O)--NR'.sub.2 or --C(O)--C(S)--R'. R' is an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R.sub.1 is a leaving group. The present invention also includes novel compounds which are intermediates in the preparation of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines.

Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines

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Malden, MA, United States of America

Reem M Haider