The University of North Carolina at Chapel Hill

Florida State University Research Foundation, Inc.

Reem K Arafa

Richard Ray Tidwell

David W Boykin

W David Wilson

Reto Brun

Karl Werbovetz

Mohamed A Ismail

Laixing Hu

Chad E Stephens

Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A, Y, and Zis N; Aris phenylene; and Aris a nitrogen-containing aromatic group. An exemplary compound of Formula (III) is: 

Substituted pyridines as antiparasitic AZA teraryl compounds

Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds. The presently disclosed compounds can include those of the formulas:  Land Lare selected from the group consisting of: 

Linear dicationic terphenyls and their aza analogues as antiparasitic agents

Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR. An exemplary compound of Formula (IIe) is: Methods for combating microbial infections, such as parasiticspecies, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.

Teraryl components as antiparasitic agents

Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to(T.b.r.) and. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.

Growing community of inventors

Cairo, Egypt

Reem K Arafa