The United States of America, As Represented by the Secretary, Department of Health and Human Services

Thomas Jefferson University

University System of Maryland

Reed F Johnson

Matthias Johannes Schnell

Lisa E Hensley

Christoph Wirblich

Christopher M Coleman

Joseph E Blaney

Peter B Jahrling

Matthew B Frieman

Matthew S Frieman

Jason Paragas

Mathias Schnell

The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.

Multivalent vaccines for rabies virus and coronaviruses

The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compositions comprising the vaccine vectors.

Multivalent vaccines for rabies virus and filoviruses

Growing community of inventors

Frederick, MD, United States of America

Reed F Johnson