Dr. Reddy's Laboratories, Incorporated

Dr. Reddy's Research Foundation

Reddy-cheminor, Inc.

Reeba Kannimel Vikramadithyan

Rajagopalan Ramanujam

Braj Bhushan Lohray

Vidya Bhushan Lohray

Ranjan Chakrabarti

Javed Iqbal

Shivaramayya Kalchar

Saibal Kumar Das

Sekar Reddy Alla

Bhuniya Debnath

Ashok Chennaveerappa Bajji

Gurram Ranga Madhavan

Gurram Ranga Madhaven

The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them

A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are the same or different; R.sup.1 and R.sup.2 together represent along with carbon atoms to which they are attached an aromatic cyclic structure containing 5-6 ring atoms which may optionally be substituted; X represents a heteroatom selected from oxygen or sulfur; R.sup.7 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl group or forms a bond together with R.sup.8 ; R.sup.8 represents hydrogen atom, hydroxy, alkoxy, halogen, lower alkyl group or optionally substituted aralkyl or R.sup.8 forms a bond together with R.sup.7 ; B represents an oxygen atom or a sulfur atom; Y represents an oxygen atom or a sulfur atom, n is an integer ranging from 1 to 4 and m is an integer of zero or one, compositions containing compounds of formula (I) and methods of use of the compounds are described.

Azolidinediones useful for the treatment of diabetes, dyslipidemia and

Novel antidiabetic compounds, their tautomeric forms, their derivatives, their analogues, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them; methods for preparing the antidiabetic compounds and their uses.

Growing community of inventors

Hyderabad Telangana, India

Reeba Kannimel Vikramadithyan