89bio, Inc.

Cephalon, Inc.

Ignyta, Inc.

Pharmacopeia Inc.

Reddeppa Reddy Dandu

Robert L Hudkins

Nadine C Becknell

Bruce D Dorsey

Craig A Zificsak

Dimitar B Gotchev

Linda Weinberg

Allison L Zulli

Kurt A Josef

Catherine P Prouty

Rabindranath Tripathy

Babu G Sundar

Edward R Bacon

Tao Guo

Sankar Chatterjee

Ming Tao

James L Diebold

Derek D Dunn

Chia-Yu Huang

Gregory J Wells

Minglang Wu

Lisa Guise-Zawacki

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

Substituted 4-benzyl and 4-benzoyl piperidine derivates

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

1,4-substituted piperidine derivatives

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses. 

Substituted 4-benzyl and 4-benzoyl piperidine derivatives

Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses. 

The present invention provides compounds of Formula I or pharmaceutically acceptable salt forms thereof, wherein R, R, R, R, D, W, R, R, R, Y, R, X, E and G are as defined herein, methods of treatment and uses thereof.

Uracil derivatives as AXL and c-MET kinase inhibitors

The present application provides compounds of Formula I or salt forms thereof, wherein R, R, R, R, D, W, R, R, R, Y, R, X, E and G are as defined herein, compositions, methods of treatment and uses thereof.

The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

Multicyclic compounds and the use thereof

The present invention provides compounds of Formula (I): their use as Hantagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.

[object Object]

Growing community of inventors

Downingtown, PA, United States of America

Reddeppa Reddy Dandu