The United States of America, as Represented by the Secretary, Department of Health and Human Services

The United States of America, as Represented by the Secretary, Departmen

Rebecca S Rudicell

Gary J Nabel

Peter D Kwong

John R Mascola

Baoshan Zhang

Yongping Yang

Ivelin Georgiev

Mark Connors

Jiang Zhu

Tongqing Zhou

Zhi-yong Yang

Gwo-Yu Chuang

John Mascola

Young Do Kwon

Wei Shi

Xueling Wu

Gilad Ofek

Jinghe Huang

Leo Laub

Zhi-Yong Yang

Leo B Laub

Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.

Broadly neutralizing HIV-1 antibodies that bind to the CD4-binding site of the envelope protein

Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.

Neutralizing GP41 antibodies and their use

Broadly neutralizing HIV-1 VRC07 antibodies that bind to the CD4-binding site of the envelope protein

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Silver Springs, MD, United States of America

Rebecca S Rudicell