Minnesota Mining and Manufacturing Company

Cornell University

Rebecca M Williams

Hsin-hsin Chou

Kam K Kam

Warren Zipfel

Watt W Webb

Alexander Gaeta

Hsin-Hsin Chou

Dimitre Gueorguiev Ouzounov

Dimitre G Ouzounov

Warren R Zipfel

A microscope apparatus and a microscopic method that uses the microscope apparatus for examining a sample or a specimen, such as but not limited to a tissue sample or a tissue specimen, includes a convex curved distal exit window at a distal end of the microscope apparatus. Due to the presence of the convex curved distal exit window, the microscope apparatus may readily make contact with the sample or the specimen absent trauma to the sample or the specimen. In addition, an index of refraction matched immersion fluid may be used for focusing the microscope apparatus by hydraulic movement of an objective optic lens assembly interior to the distal exit window with respect to the distal exit window. The convex curved distal exit window and index of refraction matched immersion fluid characteristics may be extended to various microscope apparatuses and methods, and in particular medical microscope apparatuses and methods.

Microscope apparatus, method and application

The present invention is directed to a method of applying radiation through an optical fiber for detecting disease within a plant or animal or other penetrable tissue, or imaging a particular tissue of a plant or animal. In addition, fluorescence and nonlinear scattering signals can be detected and localized within a subject by such application of radiation through an optical fiber. The radiation is effective to promote simultaneous multiphoton excitation. The optical fibers are used alone to examine internal regions of tissue, in conjunction with an optical biopsy needle to evaluate sub-surface tissue, or with an endoscope to evaluate tissue within body cavities. The present invention also relates to a device for coupling in radiation from an ultrashort mode-locked laser into the beam path of a microscope.

Optical fiber delivery and collection method for biological applications such as multiphoton microscopy, spectroscopy, and endoscopy

This invention provides a composite article comprising a support member, a controlled release material coated on the support member, and an inorganic pigment coated onto the controlled release material. In another aspect, this invention provides a method of making the same. The controlled release material comprises a first component and optionally a second component which are independently one of an organic material and an inorganic material. The composite article, which can be a donor substrate, is useful in thermal imaging.

Coated thin film for imaging

An imaging film donor sheet comprising a substrate, a controlled release/adhesive layer and a vapor-deposited colorant layer, wherein the deposited colorant layer exhibit a discernible microstructure, preferably a columnar microstructure. A matching receptor sheet is provided. A method of preparing the donor sheet as well as a method of imaging is provided.

Vapor deposited multi-layered films--a method of preparation

Vapor deposited multi-layered films--a method of preparation and use in

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Ithaca, NY, United States of America

Rebecca M Williams