Warner-lambert Company

Astellas Pharma Gmbh

Rebecca Guggemos Bakker-Arkema

Milton Lethan Pressler

Combinations of diuretics and vasopressin antagonists are useful to slow and reverse the symptoms and process of congestive heart failure, to increase the excretion of water in the urine, and to decrease the excretion of sodium and potassium ions in urine. Preferred vasopressin antagonists have the formula wherein R and Rare hydrogen or lower alkyl;

Treatment of congestive heart failure

This invention is a method for preventing or treating postoperative ileus comprising administering a vasopressin antagonist such as a compound of Formula (1), where R , R , and R include hydrogen, halo, alkyl, and alkoxy; R and R are hydrogen or alkyl; R is hydrogen, phenyl, or substituted phenyl, and pharmaceutically acceptable salts thereof.

Growing community of inventors

Ann Arbor, MI, United States of America

Rebecca Guggemos Bakker-Arkema