Amgen Inc.

Rebecca E Johnson

Ning Xi

Joseph L Kim

Brian K Albrecht

Vinod Francis Patel

Brian Lewis Hodous

Victor J Cee

Xiaotian Zhu

Yuan Cheng

Steven F Bellon

Hanh Nho Nguyen

Stephanie Geuns-Meyer

Karina Romero

Paul A Tempest

Stuart C Chaffee

Holly L Deak

Philip R Olivieri

Phillip R Olivieri

Stephanie D Geuns-meyer

Stephanie D Geuns-Meyer

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, Hand Rare defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

Protein kinase modulators and method of use

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, Hand Rare defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

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Arlington, VA, United States of America

Rebecca E Johnson