Other

Grove Instruments, Inc.

Rebecca Burrell

Hannu Harjunmaa

Stevan Kun

Georg Leuenberger

A noninvasive method for estimating a concentration of a target analyte in a sample comprises generating a first and second (reference) radiation, a principal radiation and a target analyte carrier detection radiation; directing the first, second, principal and the target analyte carrier detection radiations at the sample which includes the target analyte; and detecting a first, second, principal and target analyte carrier detection amount of the radiation that leaves the sample. The method further comprises modulating the sample thickness in order to achieve time-wise or spatial target analyte concentration variation within the sample. The method further comprises generating first, second, principal and target analyte carrier detection measurement data based respectively on the first, second, the principal and the target analyte carrier detected amounts of radiation; numerically processing the first, second, principal and target analyte carrier detection measurement data to obtain a weighted combination of the first measurement data and the second measurement data that balances the principal measurement data with respect to a sample background; and estimating the concentration of the target analyte based on the difference between the balanced weighted combination of the first measurement data and the second measurement data vs. the principal measurement data.

Noninvasive measurement of analyte concentration using methods and systems of post-balancing

An improved method for non-invasively measuring a concentration of a target analyte dissolved in a fluid flowing through a sample is presented. It includes directing a probe beam of electromagnetic radiation, having time multiplexed components of different wavelengths, where at least one of the time-multiplexed components consists of two different simultaneous wavelengths through the sample and measuring the difference of the absorption of the radiation of the time-multiplexed components at different sample states. During sample state changes, the amount of fluid containing the target analyte within the sample is changing, varying the total amount of target analyte in the sample, and the absorption properties of the sample. The sample states may be produced by compressing and uncompressing the tissue sample. The method is useful in measuring the concentration of a target analyte, such as glucose, in tissue containing blood.

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Rowley, MA, United States of America

Rebecca Burrell