Vertex Pharmaceuticals, Inc.

Vertex Pharmaceuticals (canada) Incorporated

Cytovia, Inc.

Shire Biochem, Inc.

Viro Chem Pharma, Inc.

Real Denis

Laval Chan Chun Kong

Sanjoy Kumar Das

Carl Poisson

Constantin G Yannopoulos

Louis Vaillancourt

Guy Falardeau

Rabindra Rej

Irina Motorina

Sui Xiong Cai

John Patrick Maxwell

Hong Zhang

Simon Giroux

Mark A Morris

James A Henderson

Giorgio Attardo

Songchun Jiang

Oswy Z Pereira

Bingcan Liu

Caroline Cadilhac

William E Kemnitzer

T Jagadeeswar Reddy

Youssef L Benanni

Compounds represented by formula I or pharmaceutically acceptable salts thereof, wherein A, B, B', X, Y, R, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, R, R&#x2032;, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

Analogues for the treatment or prevention of flavivirus infections

Compounds and methods for the treatment or prevention of flavivirus infections

Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.

Thiophene analogues for the treatment or prevention of flavivirus infections

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The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R, R-R, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof

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Montreal, Canada

Real Denis