Other

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Raz Yirmiya

Hermona Soreq

Tirzah Kreisel

Keren Ailon

Irit Shapira-Lichter

Ella Sklan

A pharmaceutical composition and method for treating or attenuating a mood or stress-related disorder in a subject having normal or low inflammatory state is provided. In some embodiments, the pharmaceutical composition and method of the invention comprise activating or stimulating microglia for treatment of mood or stress-related disorder.

Treatment of mood and stress related disorders

AChE antisense oligonucleotides are used as antiinflammatory agents, such oligonucleotides preferably having the sequence of SEQ ID NO:1 and SEQ ID NO:7. Methods of treatment of inflammatory conditions, as well as fever, and particularly inflammation of the gastrointestinal tract, are described.

Antisense oligonucleotides against AChE in the treatment of gastrointestinal inflammation disorders

The invention provides methods/kits for assessing levels of trait or state anxiety in a subject by comparing genotypes and/or expression patterns at the ACHE, PON1 and/or BChE genes to the genotype and/or expression pattern of the genes in a reference population whose genotype and/or expression pattern of the genes is known or by correlating AChE levels activity to those of PON.

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Jerusalem, Israel

Raz Yirmiya