The Walter and Eliza Hall Institute of Medical Research

University of California

University of Florida Research Foundation, Incorporated

Biomolecular Research Institute Ltd.

Bachem Bioscience, Ing.

Raymond Stanley Norton

Manuel Baca

Jonathan Bayldon Baell

Nicos Anthony Nicola

Sandra Elaine Nicholson

William Reade Kem

K George Chandy

Heike Wulff

Michael William Pennington

Andrew J Harvey

Katalin Kalman

Edward James McManus

Shenggen Yao

George K Chandy

Jeffrey James Babon

The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.

SOCS3 proteins

Various divalent ligands based on khellinone derivatives are described. These derivatives can be useful in the modulation of potassium channel activity in cells, including among others Kv1.3 channels found in T-cells. The compounds may also be useful in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis.

Therapeutic ion channel blocking agents and methods of use thereof

Disclosed are methods and compositions comprising DNA segments, and proteins derived from sea anemone species. More particularly, it concerns the novel ShK toxin, ShK toxin analogs, chemically-modified toxin analogs, and nucleic acid segments encoding the ShK toxin from Stichodactyla helianthus. Various methods for making and using these DNA segments, DNA segments encoding synthetically-modified ShK toxins, and native and synthetic ShK peptides are disclosed, such as, for example, the use of DNA segments as diagnostic probes and templates for protein production, and the use of proteins, fusion protein carriers and peptides in various immunological and diagnostic applications.

ShK toxin compositions and methods of use

Growing community of inventors

Ivanhoe, Australia

Raymond Stanley Norton