The Rockefeller University

Raymond Schuch

Vincent A Fischetti

Daniel Craig Nelson

Rolf Lood

Benjamin Winer

Pauline Yoong

Sherry Kan

lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization usinglysin polypeptides.

Acinetobacter lysins

The present disclosure provides recombinant phages, a Wip1 p23 receptor binding protein and a Wip1 p24 receptor binding protein that bind to. The disclosure further provides methods and uses thereof.

Recombinant phages and proteins

The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment ofandbacteria and spores, and related conditions. The disclosure further relates to methods and compositions for the identification of a phage associated lytic enzyme to rapidly and specifically detect and killand other bacteria. Related articles of manufacture, methods of degrading spores and methods of treatment of infections or bacteria populations of, or subjects exposed to or at risk for exposure to,are also provided.

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The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment ofandbacteria and spores, and related conditions. The disclosure further relates to compositions comprising various phage associated lytic enzyme that rapidly and specifically detect and killand other bacteria. Related articles of manufacture, methods of degrading spores and methods of treatment of infections or bacteria populations of, or subjects exposed to or at risk for exposure toare also provided.

The full-length nucleic acid sequence of the Cbacteriophage is disclosed in the present application. The specific regions of the Cgenome encoding the PlyC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.

Nucleic acids and polypeptides of C1 bacteriophage and uses thereof

Novel bacteriophages of, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described. Therapeutic and diagnostic compositions, methods and kits related thereto are also provided.

The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial infections. For example, bacteriophage lysins were isolated and shown to effectively kill various bacteria, including bothand(including vancomycin resistant strains), as well as other human pathogens.

Growing community of inventors

New York, NY, United States of America

Raymond Schuch