Molecular Geriatrics Corporation

Raymond Paul Zinkowski

John F DeBernardis

Daniel Joseph Kerkman

Peter Davies

Russell E Kohnken

Disclosed are compounds of formula I: wherein

Certain substituted 1-aryl-3-piperazine-1'-yl propanones

The invention relates, among other things, a preparation comprising Alzheimer's disease antigen (A68), as well as methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.

Purified antigen for Alzheimer's disease and methods of obtaining and using same

Methods for treating or preventing alzheimer's disease using substituted 1-aryl-3-piperazin-1&prime;-yl propanones

Certain substituted 1-aryl-3-piperazin-1&prime;-yl propanones

Disclosed are compounds of formula I: or the pharmaceutically acceptable salts thereof wherein

Certain substituted 1-aryl-3-piperazin-1'-yl propanones

Disclosed are compounds of formula I: ##STR1## wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl;

Substituted 1-aryl-3-piperazin-1'-yl propanones

Disclosed are compounds of formula I: ##STR1## or the pharmaceutically acceptable salts thereof wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl;

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Northbrook, IL, United States of America

Raymond Paul Zinkowski