Caridianbct Biotechnologies, LLC

Gambro, Inc.

Cobe Laboratories, Inc.

Terumo Bct Biotechnologies, LLC

The Ohio State University

Terumo Bct, Inc.

Raymond P Goodrich

Dennis J Hlavinka

Todd Curtis Green

Shawn D Keil

Vijay Kumar

Eric T Hansen

Junzhi Li

Robert Owen Lockerbie

Heather Reddy

Suzann K Doane

Matthew Stewart Platz

Larry Joe Dumont

Laura Goodrich

Christopher B Martin

Daniel McGraw

Cynthia A Scott

Daniel Mcgraw

Laura Mcburney

Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.

Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light

Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.

Preparation of vaccines using photosensitizer and light

The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.

Removal of adenine during a pathogen reduction process in whole blood or red blood cells by dilution

Methods are provided for preparation of compositions having an enhanced level of soluble alloxazine, as compared to compositions prepared using conventional techniques. Compositions and a riboflavin form having higher solubility in solution is also provided.

Methods and compositions for the production of high concentration alloxazine solutions

A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.

Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light

A method for washing multiple units of blood product including providing a centrifuge having a wash cell for each unit of blood product, balancing the centrifuge to accommodate for differences in the wash cells, and transferring supernatant including any wash solution from each unit of blood product on the centrifuge.

Methods for washing a red blood cell component and for removing prions therefrom

This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.

Preventing transfusion related complications in a recipient of a blood transfusion

This invention is directed towards a method of using visible light at wavelengths of at least 500 nm and above in combination with a sensitizer having a flavin moiety to reduce any pathogens that may be contained in blood and blood components. By exposing the blood and blood components to light of 500 nm and higher, only the sensitizer that is bound to nucleic acids of the pathogens will be activated, thus destroying the sensitizer-pathogenic nucleic acid complex. Because unbound sensitizer is not activated at this wavelength, damage to blood and blood components caused by photolysis of unbound sensitizer may be avoided.

Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components

This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and rejuvenate mitochondria and cells containing mitochondria. Mitochondrial enhancers include alloxazines and related compounds, such as riboflavin. Cells are optionally treated with photoradiation to reduce pathogens with may be present, before, after, and/or during treatment with mitochondrial enhancer. Treating with mitochondrial enhancer enables utilization of higher photoradiation energies, which achieves better pathogen reduction. When platelets are treated with mitochondrial enhancer, treated platelets may be stored for longer times than untreated platelets before they are administered to patients.

Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer

Preparation of vaccines using a photosensitizer and light

Removal of adenine during a pathogen reduction process in whole blood or red blood cell by dilution

Methods and apparatuses are provided for inactivation of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer to a fluid and exposing the fluid to photoradiation sufficient to activate the photosensitizer whereby microorganisms are inactivated.

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Lakewood, CO, United States of America

Raymond P Goodrich