At+t Corp.

The University of British Columbia

Raymond Ng

Divesh Srivastava

Bruce McManus

Virginia Chen

Zsuzsanna Hollander

Olga Kapitskaia

Hosagrahar Visvesvaraya Jagadish

Don D Sin

Casey Shannon

Scott Tebbutt

Andrew Ignaszewski

Robert Balshaw

Karen Lam

Robert McMaster

Paul Keown

Janet Wilson-McManus

Darlene Dai

Bruce Mcmanus

The present disclosure relates to methods of diagnosing acute rejection of a cardiac allograft in a subject using genomic expression profiling, proteomic expression profiling, or both on panels of nucleic acid markers and proteomic markers.

Biomarkers for the detection of acute rejection in heart transplantation

Described are compositions and methods for diagnosing acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Multiple reaction monitoring mass spectrometry (MRM-MS) was used to quantify the amount of protein biomarkers in plasma samples from human subjects. The amount of the biomarkers in the sample can distinguish AECOPD from a stable or convalescent state of COPD, or from a subject without COPD.

Methods and systems of detecting plasma protein biomarkers for diagnosing acute exacerbation of COPD

The present invention discloses the use of generalized queries, referred to as query templates, obtained by generalizing individual user queries, as the semantic basis for low overhead, high benefit directory caches for handling declarative queries. Caching effectiveness can be improved by maintaining a set of generalizations of queries and admitting such generalizations into the cache when their estimated benefits are sufficiently high. In a preferred embodiment of the invention, the admission of query templates into the cache can be done in what is referred to by the inventors as a 'revolutionary' fashion&#x2014;followed by stable periods where cache admission and replacement can be done incrementally in an evolutionary fashion. The present invention can lead to considerably higher hit rates and lower server-side execution and communication costs than conventional caching of directory queries&#x2014;while keeping the clientside computational overheads comparable to query caching.

Method for using query templates in directory caches

A method for estimating string-occurrence probability in a database comprises receiving a first probability of occurrence for each maximal substring from a plurality of substrings, each maximal substring in the plurality of substrings belonging to the string; obtaining an overall probability of occurrence; receiving a probability of occurrence for a maximal overlap of each maximal substring in the plurality of maximal substrings; obtaining a normalization factor; and dividing the overall probability of occurrence by the normalization factor to obtain the estimate.

Method and apparatus for substring selectivity estimation

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Vancouver, Canada

Raymond Ng