Mediventures Inc.

Mdv Technologies, Inc.

Basf Wyandotte Corporation

Richard E. Leach

Raymond L. Henry

Raymond L Henry

Lorraine E Reeve

Tacey X Viegas

Richard E Leach

Frederick J Foley

Stephen G Flore

Dennis V Adams

Norbert J Cremers

Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.

Method and non-gelling composition for inhibiting post-surgical adhesions

Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.

Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels

Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.

Medical uses of in situ formed gels

Balanced pH, thermo-irreversible gels comprising a polyoxyalkylene compound and an ionic polysaccharide are ideal materials for the formation of a protective contact lens over the cornea of the eye of a mammal.

Thermal irreversible gel corneal contact lens formed in situ

A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following injury to organs situated in mammalian body spaces. Aqueous, isotonic gel compositions, preferably at mammalian body fluid pH, comprising a polyoxyalkylene polymer are applied to injured areas of the organs situated in body cavities such as, the peritoneal, pelvic, or pleural cavity.

Method and composition for post surgical adhesion reduction

Compositions based upon aqueous gels for medical application, comprising polyoxyalkylene copolymers. Such gels which are isotonic, iso-osmotic, pH balanced, thermo-reversible gels are ideal vehicles for drug or diagnostic agent delivery.

Method of making thermoreversible polyoxyalkylene gels

Thermo-irreversible gel corneal contact lens formed in situ

Method and composition for post-surgical adhesion reduction

Body cavity drug delivery with thermo-irreversible polyoxyalkylene and

Balanced pH, thermo-irreversible polyoxyalkylene polymer and ionic polysaccharide gels are ideal materials for use as an ablatable mask or coating over the cornea of the eye of a mammal during excimer laser keratectomy. The depth and smoothness of the ablated corneal surface can be controlled by molding the desired surface curvature into the mask surface using a contact lens as a mold which is pressed onto the gel surface coating the cornea.

Ablatable mask of polyoxyalkylene polymer and ionic polysaccharide gel

A process and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to the peritoneal or pleural cavity or organs situated therein. Both aqueous and non-aqueous compositions comprising a polyoxyalkylene block copolymer are applied to injured areas of the peritoneal or pleural cavity or organs situated therein subsequent to surgical injury.

Growing community of inventors

Grosse Pointe Woods, MI, United States of America

Raymond L Henry