Sanofi

Raymond Kosley

Stephanie Hachtel

Stephen J Shimshock

Juergen Dedio

Elisabeth Defossa

Josef Pernerstorfer

Holger Heitsch

Marcel Patek

Aleksandra Weichsel

Rosy Sher

Carolina Lanter

Sven Grueneberg

William Jerome Bock

Charlie Chen

Chung-Yi Kung

Stephen Shimshock

The invention relates to compounds of the formula I in which R1, R2, A, B, X and Y have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.

CXCR2 antagonists

The invention relates to compounds of the formula I in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.

CXCR2 inhibitors

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Bridgewater, NJ, United States of America

Raymond Kosley