Queen's University at Kingston

Other

Raymond J Bowers

Samir P Tabash

R Stephen Brown

Arthur N Ley

Igor S Kozin

Eric J P Marcotte

Peter V Hodson

Robin A Wynne-Edwards

John G St Marseille

Kevin R Hall

Moe Hussain

Parveen Akhtar

Nico M Van Gelder

John G Stmarseille

Eric J-P Marcotte

This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples.

Detection of biological molecules by differential partitioning of enzyme substrates and products

A method of treating a CNS disorder in a subject in need of such treatment, the method comprising administering to the subject an effective amount of an N&prime;N&prime;-dichlorinated amino acid, peptide, peptidomimetic, amine, or a pharmacologically acceptable analogue or derivative thereof, such that a CNS disorder is treated. An N&prime;N&prime;-dichlorinated amino acid, peptide, peptidomimetic, or amine capable of crossing the blood-brain barrier of a subject when administered thereto.

N&prime;N&prime;-dichlorinated omega-amino acids and uses thereof

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Bath, Canada

Raymond J Bowers