American Cyanamid Company

Raymond J Biehl

Nitin V Sheth

Joseph J Valorose, Jr

Michael K Doelling

William H Marlow

Walter A Strathy

Pharmaceutical compositions comprising spherical granules including thereon or therein a 7- or 9-akylamino-6-deoxy-6-demethyltetracycline or an acid-addition salt thereof blended with at least one excipient are adapted to control the rate of drug release in the stomach and in the intenstine in order not to produce nausea or dizziness upon oral administration during antibacterial therapy.

Novel controlled release formulations of tetracycline compounds

Apparatus useful for spray coating discrete particles, such as pharmaceutical tablets, with liquid coating compositions which are essentially free of organic solvents, the apparatus having at least three spaced spray nozzles mounted on a spray manifold having a conical surface design which is located within a vertically disposed two-zone coating chamber, having a gas inlet at the chamber base adapted to project the particles to be coated through a coating zone for recirculation through a drying zone.

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Monsey, NY, United States of America

Raymond J Biehl