Wayne State University

Mayo Foundation for Medical Education and Research

Raymond Iezzi

Jose S Pulido

Kannan Rangaramanujam

Sujatha Kannan

Gary W Abrams

Jarel K Gandhi

Alan D Marmorstein

Gregory William Auner

Ratna Naik

Jane M Matsumoto

Simon Ng

James Patrick McCallister

Bharath Rajaguru

Greg Auner

Patrick McAllister

Bharath Raja Guru

Cheryl L Khanna

This document provides methods and materials for performing retinal pigment epithelium transplantation. For example, methods and materials for using fibrin supports for retinal pigment epithelium transplantation are provided.

Methods and materials for using fibrin supports for retinal pigment epithelium transplantation

Embodiments of the invention include a method for manufacturing sensors and circuit structures. The method can include providing a substrate including a layer of polymer capable of producing graphite in response to the application of energy, a first electrode adjacent to a first via location on the layer of polymer, and an insulating layer over at least a portion of the first electrode and the layer of polymer at the first via location; and applying sufficient energy to the layer of polymer at the first via location through the insulating layer to ablate the insulating layer and to form a first via as mass of graphite that extends into electrical contact with the first electrode and is surrounded by the insulating layer in a plane of the insulating layer.

Graphite biosensor and circuit structure and method of manufacture

Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.

Dendrimers for sustained release of compounds

A self-assembled nanobump array structure including a semi-absorbing outer layer provided on at least one nanobump-forming substrate layer, the semi-absorbing outer layer configured to ablate slowly to allow an applied laser energy to be transmitted to the at least one nanobump-forming substrate layer, in which the self-assembled nanobump array structure is formed by an energy and a pressure buildup occurring in the at least one nanobump-forming substrate layer.

Self-assembled nanobump array stuctures and a method to fabricate such structures

A drug delivery system includes a plurality of sites, a fluid channel for delivering a drug to one of the plurality sites, and a light channel for delivering light to an area near one of the plurality of sites. The fluid channel is a micro fluidic channel and the light channel is a wave guide. The light channel may also be a fiber optic cable. The light channel directs light at the fluid channel wherein light from the light channel does not substantially exit to the major surface. The drug delivery system selectively delivers drugs to various types of neurologic cells. In operation a solution of a photoactivatable neuro-active drug is delivered to a preselected area in vivo and photoactivated in the solution at the preselected area to stimulate neurological tissue. The neuro-active drug could be an antagonist or agonist of neuronal activity.

Method and apparatus for activating molecules to stimulate neurological tissue

Growing community of inventors

Troy, MI, United States of America

Raymond Iezzi