Otsuka Pharmaceutical Company, Limited

Proteus Digital Health, Inc.

Other

Tire Service Equipment Mfg. Co., Inc.

Raymond H Schmidt

Hooman Hafezi

Patricia Johnson

Mark Zdeblick

George M Savage

Lawrence W Arne

Aditya Dua

Robert C Leichner

Zahedeh Hatamkhany

Jafar Shenasa

Timothy Robertson

Robert Duck

Jeremy Frank

Robert Azevedo

Peter Bjeletich

Kurt Scheinpflug

Nikhil Pargaonkar

Chris Dong

Veeraperumanallu Muralidharan

Hiren Patel

Nikolaus Leist

Anuj Patel

Kosuke Iwai

Kevin K Cheng

Maria Holen

Ai Ling Ching

Richard Huang

Alvin Thai

Veeraperurnanallu Muralidharan

Wesley G Sprunk

Kevin Cheng

Improved ingestible event markers are provided. Aspects of the markers may include the presence of a matrix layer that includes a binder and source of an electron acceptor. Alternatively or in addition to the matrix layer, aspects of the markers may include a large surface area electrode having a surface area that exceeds the surface area of the circuitry of the marker. Aspects further include methods of making and using the ingestible event markers.

Enhanced ingestible event indicators and methods for making and using the same

An apparatus includes a food product, at least one ingestible device associated with the food product to communicate information and at least one coating material surrounding the at least one ingestible device is disclosed. The ingestible device is associated with an ingestible medication to be ingested in conjunction with the food product. The coating is configured to release the at least one ingestible device upon the occurrence of an event.

Masticable ingestible product and communication system therefor

Various methods and apparatuses are presented for an ingestible capsule that includes a digital, ingestible sensor component&#x2014;or ingestible sensor&#x2014;embedded into the capsule. The ingestible sensor component may be configured to activate upon coming into contact with conductive fluid, such as a body's stomach fluid. Once activated, the ingestible sensor component may be configured to perform various tasks, such as transmitting one or more signals and obtaining biometric data about the body that ingested the capsule.

Methods for manufacturing capsules with ingestible event markers

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

Ingestible device with pharmaceutical product

The present invention discloses multiple approaches to preventing the capsule walls and other material from interfering with the performance of an electronic device once the device is activated by surrounding fluid. In accordance with the teachings of the present invention, a miniature ingestible device (MID) may be created using excipients and films. The MID, in accordance with various aspects of the present invention, will have a coating or laminating surrounding an electronic device and separating and isolating the device from the pharmaceutical product or drug within the capsule once the capsule is ingested as well as from the capsule itself as the capsule walls begin to collapse during the disintegration process.

Miniature ingestible device

Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions.

Highly-swellable polymeric films and compositions comprising the same

An ingestible compositions includes a first polymer layer, an adhesive layer associated with the first polymer layer, where the adhesive layer includes an adhesive material and is configured to releasably adhere to the first polymer layer, an alginate layer adhered to the adhesive layer, and a second polymer layer associated with the alginate layer and configured to releasably adhere to the alginate layer. Aspects further include methods of making and using the compositions.

Alginate on adhesive bilayer laminate film

Provided is an apparatus, system, and method for detecting a metal contaminant in a sensor-enabled dose form. According to the method, a sensor-enabled dose form is oriented in a predetermined orientation. The sensor-enabled dose form is received through an aperture of a metal detector. A detection signal is generated by the metal detector in response to receiving the sensor-enabled dose form through the aperture of the metal detector. The detection signal is compared to a predetermined threshold. The presence of a metal contaminant in the sensor-enabled dose form is determined based on the comparison of the detection signal and the predetermined threshold. In another method, the sensor-enabled dose form is first oriented in a first orientation and then in a second orientation. The apparatus includes a guide, a metal detector, and a comparator circuit. The system further includes a controller to reject contaminated sensor-enabled dose forms.

Metal detector apparatus, system, and method

Growing community of inventors

Buffalo, MN, United States of America

Raymond H Schmidt