Merck + Co., Inc.

Raymond E Spier

William J McAleer

Kenneth L Posch

William J Miller

Clarence L Baugh

Abner J Schlabach

Production of cells and vaccines utilizing a multiplate propagator in which the fluid dynamics of the system can be controlled during the growth cycle and/or the harvesting conditions can be controlled by rapidly cooling the harvested vaccine or by using multiple harvests, with or without automated collection of the vaccine thereby producing cells and vaccines in significantly increased yields and at substantially reduced costs in comparison with presently utilized procedures.

Cell and vaccine production

Cell growth surfaces having controlled surface topography which permits the optimization of the fit between the cells and the growth surface. These surfaces may be constructed from sintered or sputtered titanium, glass, ceramic, plastic, or stainless steel, or may consist of a substrate having microspheres adhered to the surface thereof.

Process for producing a live virus vaccine for the immunization of chickens against Marek's disease utilizing a multiplate machine.

Process for production of vaccines

A process for the controlled manufacture of cells and vaccines in which reproducable real time quantitative assays are utilized to ascertain the physical and chemical state of the system, in order to more efficiently manage the system, so that cell sheet formation may be determined and the vaccine may be harvested at its maximum titre, thereby resulting in significantly increased yields and decreased production costs.

Vaccine production

A multiplate propagator for producing cells and vaccines having critical geometric properties such as ratio of plate diameter to internal tank diameter results in significantly increased yields at substantially reduced costs.

Growing community of inventors

Lansdale, PA, United States of America

Raymond E Spier