Vertex Pharmaceuticals, Inc.

Bionomics Inc.

Ironwood Pharmaceuticals, Inc.

Cardurion Pharmaceuticals, LLC

Raymond E Forslund

Gerald J Tanoury

Bernard Luke Flynn

Andrew John Harvey

Dharam Paul

Minzhang Chen

Young Chun Jung

Song Xue

Ahmad Hashash

Vasu Sethuraman

Rob Livingston

Francois Maltais

Robert B Perni

Youssef L Bennani

Gregor Zlokarnik

Adam R Looker

William Aloysius Nugent

Cristian Harrison

Theodore A Martinot

Shereen Ibrahim

Anuj K Kumar

Disclosed herein are thienopyrimidine meglumine salts according to Formula (I) used for treating or preventing heart failure: 

Meglumine salts of thienopyrimidines

The present invention provides crystalline Forms FUM-P3, FUM-P4, MLA-P3 and MLA-P4 of compound formula 1 and related methods of treating and/or preventing a disease, such as a central nervous system disease (e.g., an anxiety disorder), using a crystalline Form FUM-P3, FUM-P4, MLA-P3 and MLA-P4 of compound formula 1 and/or pharmaceutical compositions thereof. 

Salts, co-crystals, and polymorphs of an anxiolytic compound

The present invention provides amorphous arid crystalline forms of 1-ethyl-6-(indan-2-ylamino)-3-(morpholine-4-carbonyl)-1,8-naphthyridin-4-one (compound 1), and salts, co-crystals, and pharmaceutical compositions thereof. The invention also provides methods of treating and/or preventing a disease, such as a central nervous system disease (e.g., an anxiety disorder), using the amorphous and crystalline forms, and salts, co-crystals, and pharmaceutical compositions thereof.

This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R, R'and Rare defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.

Processes and intermediates for preparing steric compounds

The invention provides &#x3b2;-sulfonamide &#x3b1;-keto esters and amides in which the &#x3b1;-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.

Preparation of protected alpha-keto beta-amino esters and amides

This invention relates to processes and intermediates for the preparation of salts of deuterated, enantiomericallv enriched alpha-amino beta-hydroxy acids of Formula 1 wherein the variables R,R'and R&#x2032;are defined herein, and wherein the process may comprise the steps of forming a salt of a compound of Formula 1, and crystallizing said salt to give a compound of greater than 55% enantiomeric excess.

Deuterated hepatitis C protease inhibitors

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Natick, MA, United States of America

Raymond E Forslund