Euveda Biosciences, Inc.

Raymond Cheong

Saurabh Paliwal

Zhizhong Yin

Microfluidic devices have been developed to perform a range of high-throughput biochemical and cell-based assays over recent years. A design for a microfluidic device has been developed that resembles a microtiter plate, by placing the test chambers (each test chamber contains cells) and top-loading drug inlets (at least one per test chamber) in a grid according to the ANSI/SBS standards, yet offers the miniaturization and fluid handling advantages of microfluidics. This ensures that the device design is compatible with fluid handling and imaging equipment already in use for drug screening. A range of topologies have been determined that allow placement of various elements of this microfluidic network within the grid alignment constraints. A resistance equalization methodology has also been developed to reduce variability across assays run in different chambers of the microfluidic device. Additionally, it offers orders of magnitude miniaturization over multiwell plates, and potentially more reliable fluid handling.

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Timonium, MD, United States of America

Raymond Cheong