Commissariat a L'energie Atomique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Biomerieux, Inc.

Totalenergies Onetech

Cnrs

Serono Genetics Institute S.a.

Raymond Charles

Yves Fouillet

Patrick Pouteau

Cyril Delattre

Jean-luc Achard

Nicolas Sarrut

Patricia Claustre

Michel Borel

Florence Ricoul

Fabien Sauter-Starace

Michel Ida

Alim-Louis Benabid

Olivier Constantin

Aim&eacute; Perrin

Bertrand Bourlon

Jean-Frederic Clerc

Remco Den Dulk

Manuel Alessio

Hubert Jeanson

Jean Luc Achard

Claude Vauchier

Christine Peponnet

Nicolas Sarrut-Rio

Ernest Galbrun

Jean Malinge

Camille Echampard

Pierre Souquet

François Boizot

Mélissa Baque

Anne-Gaëlle Bourdat

Amélie Bellemin Comte

Frédéric Progent

An automated system for preparing, detecting and analyzing a first fluid sample containing biological species, the preparation, detection and analysis system including at least one fluidic cartridge that includes at least one fluidic concentration and lysis module and one fluidic detection module including an array of several amplification chambers arranged in parallel, an apparatus including a mechanical assembly comprising at least one movable rod fastened to the frame and comprising a free end arranged to cooperate with a flexible membrane of the fluidic concentration and lysis module, an optical measurement system for measuring fluorescence through one or more amplification chambers of the fluidic detection module of the cartridge, a control and processing unit.

Automated system for preparing, detecting and analysing a fluid sample

A fluidic card including a rigid support and a fluidic channel at least partially formed in the rigid support. The fluidic channel includes an opening coming out on an outer surface of the rigid support, and the fluidic card further includes a flexible film disposed on the outer surface of the rigid support, at least at the opening of the fluidic channel, the flexible film configured to be deformed between a closed position in which it enables the fluidic channel to be closed to prevent a fluid flow from the fluidic channel through the opening and an open position in which it allows presence of a fluid flow space from the fluidic channel through the opening.

Fluidic card comprising a fluidic channel provided with an opening resealable by means of a flexible film

A device for interconnecting a card including at least one first fluid channel, emerging from a connection side parallel to a support side, the interconnection device including: a first surface configured to receive the support side of the card; a second surface parallel to the first surface, from which a second fluid channel emerges; and a mechanism to hold the card in place, configured to hold a connection side of the card pressed against the second surface of the device, such that first fluid channel is in fluid connection with the second fluid channel.

Microfluidic card connection device

A transcranial securing device for deep brain stimulation leads comprising: a principal part for securing inside an opening formed in the cranium of a patient; and at least one first securing part housed inside said principal part; said or each securing part comprises at least one axial bore adapted to allow the passage of one or more deep brain stimulation leads; said or at least one securing part is arranged so as to be capable of passing from a first position in which the lead or leads can slide axially in the respective bores, to a second position in which it grips the lead or leads in the respective bore or bores, preventing said sliding.

Transcranial securing device for deep brain stimulation leads

The method for controlling the progression of a fluid, from upstream to downstream, in a microfluidic component comprising for example a plurality of microchannels each comprising a plurality of successive reaction or detection zones and a plurality of passive valves, controls the progression of the fluid in the microchannels by controlling the increase of a pressure difference between upstream and downstream of the component. The method controls the pressure difference increase discontinuously in the form of enabling pulses so as in particular to synchronize passing of the corresponding passive valves of the microchannels. The pressure difference is advantageously adjusted to a zero value between two successive enabling pulses.

Method for controlling the progression of a fluid in a microfluidic component

The invention concerns a device for air/water extraction by semi-humid electrostatic collection, comprising a chamber () containing a discharge electrode () for generating an ion flow from an ionized gas accumulation surrounding the discharge electrode () and a counter-electrode (), an inlet () for mixing air and aerosol to be extracted which contains liquid or solid particles, a steam supply tube () and an outlet () for the cleansed air. The invention is characterized in that the device enables steam to be introduce the steam supply tube () in the gap between the discharge electrode () and the counter-electrode () so as to form a steam sheath () enclosing the discharge electrode over its entire length, such that the treated air is not steam-saturated.

Device for air/water extraction by semi-humid electrostatic collection and method using same

The recess () between the main connecting part () and a collar () contains a toroidal or otherwise shaped sealing ring or joint () and the end of a tube () incorporating an outer flange (), whose thickness becomes zero at the crushing bulge () of the sealing ring (). An excellent seal is ensured at this location, even for pressurized fluids, and the assembly can easily be dismantled.

Micro-tube connection

The invention concerns the performing, in continuous flow, of a biological, chemical or biochemical protocol on substances to be analysed, comprising several steps which consists in: in causing a mobile analysis support () comprising means () for receiving substances to be analysed and reagents to move past; implementing the steps of the protocol on the substances as the mobile analysis support () moves past.

Method and system for performing in continuous flow a biological, chemical or biochemical protocol

The invention relates to a device () for distribution of at least one liquid product, the device comprising at least one injection tube () supplied by a liquid product and being provided with an outlet orifice () capable of cooperating with an inlet orifice () of a reception tube () for reception of each liquid product. According to the invention, the outlet orifice () of each injection tube () and the inlet orifice () of the reception tube () open up into a sealed reservoir () full of an immiscible liquid (), the outlet orifice () of each injection tube () being at a spacing from the inlet orifice () of the reception tube () and able to be located close to the reception tube (), the device () also comprising means () for pressurizing the immiscible liquid ().

Liquid product distribution device and method

The invention relates to a device for displacement of at least a small volume of liquid () under the effect of an electrical control, including a substrate () provided with first electrically conducting means (), the device also comprising second electrically conducting means () arranged facing the first electrically conducting means (), the first electrically conducting means and the second electrically conducting means possibly being connected to electrical power supply means to enable the application of electrostatic forces to the small liquid volume (). The second electrically conducting means include at least one conducting wire () arranged parallel to the substrate and at a fixed distance from the substrate to enable displacement of the small volume of liquid () along said conducting wire () under the effect of the applied electrostatic forces.

Device for displacement of small liquid volumes along a micro-catenary line by electrostatic forces

Devices and methods for carrying out a chemical or biochemical protocol are disclosed. In one embodiment, the chemical or biochemical protocol is performed by cycling at least one thermal transfer member between at least two temperatures while liquid samples on which the chemical or biochemical protocol is to be performed are continuously moving through at least one temperature regulated zone upon which the at least one thermal transfer member acts. In some embodiments, the device comprises a sample transport member that comprises liquid samples in sample receiving regions. The sample transport member moves the samples continuously through a temperature regulated zone which cycles between at least two temperatures while the liquid samples are moving through a temperature regulated zone on which at least one thermal transfer member acts. In some embodiments, the sample receiving regions comprise wells, hydrophillic films or hydrophillic filaments.

Method for carrying out a biochemical protocol in continuous flow in a microreactor

An apparatus for depositing a material by evaporation on a substrate having a large surface. The apparatus includes an enclosure in which are placed a number of material evaporation sources. It also includes a device for channeling or piping of vapors emitted by the sources toward the substrate during evaporation. This is formed by walls or covers which define compartments within the enclosure, each evaporation source being placed in a compartment. The apparatus can also utilize a device for moving the substrate in order to improve the uniformity of the deposit.

Apparatus for depositing a material by evaporation on large surface substrates

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Saint Jean de Moirans, France

Raymond Charles