Eli Lilly and Company

Dowelanco

American Cyanamid Company

Dow Agrosciences LLC

Otis W., Jr. Godfrey

Tom E. Eaton

Hang Chio

Laverne D. Boeck

Karl H. Michel

Raymond C. Yao

Walter M. Nakatsukasa

Raymond C Yao

Robert L Hamill

Karl H Michel

Walter M Nakatsukasa

Otis W Godfrey

David F Mahoney

Manuel Debono

LaVerne D Boeck

Anne H Dantzig

R Michael Molloy

Tom E Eaton

Dennis R Berry

Donald B Borders

Raymond T Testa

Laura Lee Karr

May D Lee

Jeffrey Ryan Gilbert

Paul Richard Graupner

James A Mabe

John H Martin

Paul Lewer

Richard M Gale

Donald R Hahn

Thomas V Worden

Dennis W Norton

Lawrence E Doolin

Marvin M Hoehn

David S Fukuda

Jon S Mynderse

Rosanne Bonjouklian

Milton J Zmijewski

Jeffrey T Fayerman

Tim A Smitka

Michael D Jones

Laverne D Boeck

Jr Godfrey Otis W

Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.

Pesticidal macrolides

New glycopeptide antibiotic A82846, comprising A82846A, A82846B and A82846C, is produced by Nocardia orientalis strains NRRL 18098, NRRL 18099 and NRRL 18100. The A82846 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.

A82846 antibiotics

Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A83543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided.

Insecticide and miticide compositions containing A83543 compounds

New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.

Antibiotic A82810

Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.

Insecticide and miticide A83543 compounds and their method of production

Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.

A87689 compounds

New glycopeptide antibiotic A83850, comprising A83850A, and A83850B, is produced by Amycolatopsis albus strain NRRL 18532. A83850A and A83850B can be reduced to give new biologically active denatures. The A83850 antibiotics have activity against Gram-positive bacteria comparable to that of vancomycin.

A83850 antibiotics

Process for producing A83543 compounds

A87689 compounds employed as a phospholipase A.sub.2 (PLA.sub.2)

Method for treating swine dysentery with the derivatives of the

A new microorganism, Streptomyces avermitilis subspecies niger NRRL 21005, and processes using the microorganism for producing known avermectins are provided.

Strain of streptomyces for producing avermectins and processes therewith

Newly discovered lipoglycopeptide antibiotic A84575 complex, comprising factors A, B, C, D, E, F, G, and H, is produced by submerged aerobic fermentation of a culture selected from Streptosporangeum carneum NRRL 18437, Streptosporangeum carneum NRRL 18505 or an A84575-producing mutant thereof. The antibiotics are active against Gram-positive bacteria.

A84575 antibiotics

Amycolatopsis mediterranei strains useful to prepare A87689 compounds

Growing community of inventors

Carmel, IN, United States of America

Raymond C Yao