Other

Janssen Pharmaceutica Nv

Raymond C Ng

Zhihua Sui

James C Lanter

Vernon C Alford, Jr

Jihua Guan

Nareshkumar F Jain

Ramesh M Kanojia

Jiayi Xu

Mark J Macielag

William V Murray

James C Caillouette

Arthur L Silber

The present invention is directed to novel benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS)

Benzimidazole derivatives useful as selective androgen receptor modulators (sarms)

The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators

The present invention is directed to novel cyclohexyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.

Cyclohexyl derivatives as selective estrogen receptor modulators

A flow-controlling tampon, comprising a generally upright elongated sheath structure having an open upper end and a closed lower end, the upper end sized to fit about the cervix an inner, elongated, flow-control tube extending generally upright within the sheath, the tube having an upper open end to receive flow via the upper open end of the sheath, and the flow-control tube having lower opening structure to pass flow from the tube into the lower interior of the sheath to gradually collect upwardly from the lower interior of the sheath, and about the control tube.

Toxicity resistant tampon structure

A method for sheathing speculum arms, utilizing the combination comprising a holder sheet structure having spaced sections; first and second sheaths extending in substantially parallel relation between the sections, the sheaths respectively associated with the sections, the sheaths defining entrance openings for penetration by the respective arms whereby the arms are insertible into the sheaths, to carry the sheaths; and the holder sheet structure then being separable from the sheaths whereby the speculum arms carrying the sheaths are then usable for vaginal examination.

Method for speculum sheathing and sheathing use

A surgical needle guide apparatus comprising a substantially horizontal base to be applied to a surface on or adjacent a patient's body surface zone to be punctured by the needle; an upright guide flange mounted on the base, there being pivot structure associated with the flange and base and projecting beyond the base, to overhang an open zone adjacent the surface and offset from the flange; and elongated, tubular guide structure having a lower end portion carried by the pivot structure to be manually pivoted so that the needle structure swings adjacent the guide flange, the tubular structure adapted to receive needle structure for guiding movement thereof toward the open zone and at an angle determined by selective swinging of the tubular guide structure relative to the base.

Disposable universal needle guide apparatus (for amniocentesis)

A fluid aspiration needle assembly comprising a linearly elongated, tubular needle having a first end to be positioned at or proximate a patient's body, and an opposite end portion; a hub integral with the opposite end portion of the needle and providing a reservoir, the hub having a first duct in linear communication with the needle via the reservoir, and there being a second duct in communication with the reservoir and branching relatively away from the first duct, the second duct connected to the hub; the first duct, reservoir and needle being in linear alignment to receive an elongated stylet having a sharp end, and manipulable to cause the sharp end to penetrate the patient's body, and to be withdrawn so that body fluid can pass through the needle and enter the reservoir; and flexible, coupler tubing operatively connected to the second duct for passing fluid between the reservoir and a syringe operatively connected to the reservoir via the flexible tubing, whereby the syringe may be bodily manipulated in force-transmitting relation isolation relative to the needle.

Fluid aspiration needle

A suctioning device is provided for use in removal of fluid mucus from the trachea and nostrils of a newborn infant, to prevent aspiration of such fluid into the infant's lungs before first breath; the device includes a vertically, longitudinally, upright container having a bottom wall with an opening therein to pass mucus into the container via a tubular catheter, and a top cap with an opening therein to pass suction air from the container interior toward a suction mouthpiece; a baffle or baffles in the container to intercept upward flow of mucus toward the top cap; a duct in the container to receive flow of mucus via the opening sin the bottom wall, the duct having an outlet end located to eject mucus to fall in a generally downward direction in the container, below the baffle; and a filter or filter above the duct to filter air being sucked from the container interior toward the mouthpiece via the top cap opening. The filter and one part of the baffle are typically carried by the top cap for endwise insertion downwardly into the container upper extent, the bottom wall is typically defined by a bottom cap received in the container, and the duct and a second part of the baffle are typically carried by the bottom cap for endwise insertion upwardly into lower end extent of the container.

Neonstal mucus extractor

A monitoring transducer positioning apparatus, for retention to the body of a patient, comprising an inverted generally cup-shaped holder to receive and position the transducer, first structure associated with the holder to retain it to the patient's body, and second structure on the holder to urge the transducer toward the patient's body, relative to the holder.

Holder apparatus for transducer applicable to human body

A suctioning device is provided for use in removal of fluid mucous from the trachea and nostrils of a newborn infant, to prevent aspiration of such fluid into the infant's lungs before first breath; the device includes:

Growing community of inventors

San Marino, CA, United States of America

Raymond C Ng