Ilex Products, Inc.

Other

Smithkline Beecham Corporation

Symphar S.a.

Ilex Oncology Research S.a.

Raymond Azoulay

Eric Joseph Niesor

Craig Leigh Bentzen

Hieu Trung Phan

Vinh Van Diep

Robert John Ife

Lan Mong Nguyen

Simon Floret

Yves Guyon-Gellin

Alexandre Bulla

Jean-Luc Thulliard

Harald Eschenhof

Yves Gyon Gellin

Lân Mong Nguyen

Anne Perez

The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.

Aminodiphosphonate apolipoprotein E modulators

The present invention relates to novel &#x3b2;-substituted-&#x3b2;-aminoethylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

&#x3b2;-substituted &#x3b2;-aminoethyl phosphonate derivatives

The present invention relates to novel &agr;-substituted-&bgr;-aminoethylphosphonate and &agr;-substituted-&bgr;-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

&agr;-Substituted &bgr;-aminoethyl phosphonate derivatives

Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.

Compounds and pharmaceutical compositions containing them

Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity.

Pharmaceutical aminophosphonic acid derivatives

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Genève, Switzerland

Raymond Azoulay