Hoffmann-la Roche Inc.

Roche Diagnostic Systems, Inc.

Raymond Albert Hui

Kathryn Sarah Schwenzer

Salvatore Joseph Salmone

Steven Mark Rosen

Novel benzpyran derivatives and the use of these derivatives in producing novel anti-cannabinoid antibodies are disclosed. Also disclosed is the use of these antibodies as reagents in improved immunoassays for tetrahydrocannabinol metabolites in biological fluid samples.

Reagents for a cannabinoid immunoassay

Compounds of the formula ##STR1## wherein F is a fluorescing compound; Y is --NH-- or a single covalent bond; Z is a straight or branched alkylene chain of 2 to 10 carbon atoms which is substituted by at least one hydrophilic group; Q is oxygen or sulfur; and X is a ligand-analog, the ligand-analog capable of being recognized by an antibody specific to the corresponding ligand. These compounds have improved properties in fluorescence polarization immunoassays by possessing either a better intensity and/or a larger span.

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Lyndhurst, NJ, United States of America

Raymond Albert Hui