Wisconsin Alumni Research Foundation

Other

Ray Vanderby

Hirohito Kobayashi

John A Kink

Peiman Hematti

Peter Muir

Sarah Kuehl

William A Sethares

Paolo Pepe Provenzano

Connie Sue Chamberlain

Mon-Ju Wu

Joseph Karls

Kelley W Grorud

Kelley Dwyer Grorud

Anna Elizabeth Breiner Clements

Anna Clements

Connie Chamberlain

Disclosed are formulations for providing an active agent. Formulations include a carrier including an active agent and mineral coated microparticles wherein an active agent is adsorbed to the mineral. Other formulations include a carrier including mineral coated microparticles wherein mineral coated microparticles include an active agent. Also disclosed are methods for sustained delivery of an active agent and methods for treating inflammatory diseases using a formulation for providing sustained delivery of an active agent.

Mineral coated microparticles for sustained delivery of biologically active molecules

An ex vivo generated population of tissue-specific alternatively-activated macrophages and methods of making and using such macrophages for treating orthopedic injury are provided.

Macrophage cell therapy to treat orthopedic injury

An ultrasound imaging system combines successive images of a time series to produce high-resolution ultrasound. A piecewise registration process and deemphasizing of high-frequency spatial components may be used to aid in the combination process. A high-definition image may be obtained with or separately from this process by combining different images obtained with different ultrasound frequencies. The images are weighted to accentuate the contribution of high-frequency ultrasound data at the leading edge of imaged structure.

Ultrasound machine providing composite image data

An ultrasound machine processes ultrasonic data according to acoustoelastic properties of the materials to obtain strain information without specific assumptions with respect to the material properties of the measured material or a variety of different material properties normally not obtained by ultrasound machines.

Method and apparatus using lateral access to obtain acoustoelastic extraction of axial material properties

Method and apparatus for acoustoelastic extraction of strain and material properties

Disclosed are methods for detecting and treating joint disease. The methods of diagnosis include determining increased expression of enzymes that are upregulated during the progress of joint and ligament inflammation and degeneration. In addition, disclosed are methods of treating the disease including inhibiting the activity of responsible proteases.

Method to diagnose and treat degenerative joint disease

Disclosed are a method and a corresponding pharmaceutical composition for treating damaged cartilage and subchondral bone. Neurogenic compounds in general and neuropeptides in particular have been found to be highly effective in stimulated repair of cartilage and bone damaged due to traumatic injury, ligament disease, and disuse. Preferred active ingredients for use in the method and corresponding pharmaceutical composition include calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), dynorphin, enkephalin, galanin, neuropeptide Y (NPY), neurotensin, somatostatin, substance P (SP), thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide (VIP).

Use of neuropeptides for traumatic cartilage injury

Disclosed are a method and a corresponding pharmaceutical composition for treating damaged ligaments. Neurogenic compounds in general and neuropeptides in particular have been found to be highly effective in stimulated repair of ligaments damaged due to traumatic injury, ligament disease, and disuse. Preferred active ingredients for use in the method and corresponding pharmaceutical composition include calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), dynorphin, enkephalin, galanin, neuropeptide Y (NPY), neurotensin, somatostatin, substance P (SP), thyrotropin-releasing hormone (TRH), vasoactive intestinal peptide (VIP).

Use of neuropeptides for ligament healing

The variation in acoustic properties in soft tissues, such as biological tissues, as a function of strain may be modeled to improve elastographic measurements and to obtain direct measurements of strain or material properties and pre-stress.

Growing community of inventors

Madison, WI, United States of America

Ray Vanderby