Inspirion Delivery Sciences, LLC

Ohemo Life Sciences, Inc.

Oheno Life Sciences, Inc

Inspirion Delivery Technologies, LLC

Ray Difalco

Manish S Shah

An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.

Abuse resistant drugs, method of use and method of making

Abuse resistant forms of extended release morphine with oxycodone, method of use and method of making

Abuse resistant oral opioid formulations

Abuse resistant forms of immediate release oxycodone, method of use and method of making

Abuse resistant forms of extended release hydromorphone, method of use and method of making

Abuse resistant forms of extended release hydrocodone, method of use and method of making

Abuse resistant forms of extended release morphine, method of use and method of making

Abuse resistant forms of extended release oxymorphone, method of use and method of making

An oral pharmaceutical composition comprising a drug and one or more pharmaceutically acceptable excipients in a monolithic dosage form, wherein the dosage form is configured such that when the dosage form is divided into more than one piece and at least one of the pieces is administered to a subject the Cmax, AUC, and/or rate of drug released after administration is substantially the same or lower and the Tmax is higher than the Cmax, AUC, rate of drug released, and/or Tmax after administration of: (1) a comparable composition in intact dosage form of equal drug dosage of the administered at least one piece; (2) a bioequivalent drug composition in an intact dosage form of equal drug dosage to the administered at least one piece; and (3) a divided piece of a bioequivalent drug composition, wherein the divided piece comprises a drug dosage equal to the dosage of the administered piece of the oral composition. Methods of making the same and methods of using the same are also provided.

Pharmaceutical compositions configured to deter dosage form splitting

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Ridgewood, NJ, United States of America

Ray Difalco