The Cleveland Clinic Foundation

Ray Dessoffy

Kiyotaka Fukamachi

Jamshid Karimov

Shubhayu Basu

Eugene J Jung

Alex Massiello

Mariko Kobayashi

A device for minimizing obstruction in a medical device that carries fluids includes a housing defining a channel configured to receive and secure a section of the medical device such that the section of the medical device extends coaxially with a central longitudinal axis of the channel. The device also includes components supported in the housing, including a motor, wherein the components are configured to be operated to impart motion to the housing and the attached medical device. The motion is configured to produce oscillatory motion of a frequency sufficient to concentrate shear stresses in a fluid boundary layer adjacent an inner wall of the medical device. The housing and the components supported in the housing are configured and arranged so that a device center of mass lies along or near the longitudinal axis of the channel.

Motion-assisted systems, devices and methods for minimizing obstruction of medical devices

Systems, devices and methods for minimizing or preventing catheter or other medical device occlusion. Mechanical motion is applied to the inner and outer walls of the catheter to minimize blood clots or other biological substances from obstructing the catheter and to help maintain catheter patency.

Treatment of heart failure in a patient by electrically modulating both the sympathetic and parasympathetic autonomic cardiac nerve fibers that innervate the patient's heart at an extravascular site in the pericardial space of the heart. The extravascular site is any suitable single location inside the chest cavity that carries both sympathetic and parasympathetic cardiac nerves such as the cardiac plexus or the pericardial transverse sinus or any two separate extravascular sites with one site carrying predominantly sympathetic cardiac nerves and the other site carrying predominantly parasympathetic cardiac nerves for electrically modulating the balance of autonomic cardiac nerve control. Physiologic inputs from a neuromodulation system's own sensors or from separate implanted or external cardiovascular hemodynamic sensor systems can be used for closed loop control over the balance of sympathetic and parasympathetic cardiac autonomic effects on the patient's cardiac function in real time response to chronic and transient physiologic needs.

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Parma, OH, United States of America

Ray Dessoffy