Sun Pharmaceutical Industries Limited

Ravishankara Madavati Nagaraja

Rajamannar Thennati

Muthukumaran Natarajan

Nishith C Chaturvedi

Dhiren Rameshchandra Joshi

Brijeshkumar Patel

Rishit Mansukhlal Zalawadia

Abhishek Tiwari

Krunal Harishbhai Soni

Vinod Sampatrao Burade

Vipulkumar Shankarbhai Patel

Pradeep Dinesh Shahi

Kunal Pandya

The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.

GLP-1 analogues

Growing community of inventors

Gujarat, India

Ravishankara Madavati Nagaraja