Laboratorios Lesvi, S.l.

Ravindranath Vishnu Newadkar

Pere Dalmases Barjoan

Juan Huguet Clotet

Avinash Changdeo Gaikwad

Ajay Madhukar Harad

Anil Purushottam Joshi

Santosh Kumar Singh

Isabel Navarro MUÑOZ

Anil Puruschottam Joshi

Samir Raghunath Bendre

Deepak Hemant Jere

The present invention provides a process for obtaining dronedarone or salts thereof characterized in that in an organic phase comprising one or more non-polar solvents, 5-amino-3-[4-(3-di-n-butylaminopropoxy)benzoyl]-2-n-butyl-benzofuran is reacted with methane sulfonyl chloride without the addition of a base. The invention also provides a process for obtaining intermediates of dronedarone environmentally friendly and industrially viable.

Process for obtaining dronedarone

The invention relates to a method and compounds for the preparation of clevidipine butyrate, a very short acting hypertensive calcium antagonist, as well as the synthesis of these compounds useful for the preparation of clevidipine (also known as clevidipine butyrate). Moreover the invention also discloses polymorphic forms of clevidipine butyrate, useful for the preparation of pharmaceutical compositions, and processes to prepare them.

Preparation of dihydropyridines

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Thane-Maharashtra, India

Ravindranath Vishnu Newadkar