Health Research, Inc.

The State University of New York

General Electric Company

University of California

University of Michigan

Zhejiang Hisun Pharmaceutical Co., Ltd.

Photolitec, LLC

Schlage Lock Company LLC

The Research Foundation of Suny

Ravindra Kumar Pandey

Thomas J Dougherty

William R Potter

Allan R Oseroff

Peter Kanter

Yihui Chen

Zachary Grossman

Munawwar Sajjad

Anurag Gupta

Raoul Kopelman

Kevin M Smith

Heinz Baumann

Amy L Gryshuk

Nayan Patel

Manivannan Ethirajan

Lalit Goswami

Penny Joshi

Hua Bai

Scott Roger Finn

John J Fitzgerald

Zhenliang Chen

Harry Israel Ringermacher

Donald Robert Howard

Jonathan Lovell

Alexander J Pallenberg

Shuai Shao

Khurshid Guru

Earl Jim Bergey

Evan Earl Evans

William G Cance

William Elliot Bachrach

Chao Liu

Farukh Durrani

Elena V Kurenova

Indrajit Roy

Richard Mazurchuk

Haridas Pudavar

Andrei N Kozyrev

Joseph A Spernyak

Kevin Carter

Isabelle Meunier

William Elliott Bachrach

Donald Frederick Mowbray

Mahabeer Dobhal

Janet Morgan

Erin Tracy

Lohithaswa Thimmappa

Vinod Kumar Rajan

Aravinda Mahabaleshwara

Joseph Cacaccio

Roger Kanaan

Suresh Pandey

Kevin Siters

Stephanie Pincus, Legal Representative

Hani A Nabi

Tymish Y Ohulchansky

Andrei Kozyrev

Xiang Zheng

Nadine Jagerovic

Avinash Srivatsan

Joseph M Ryan

Ravindra Cheruku

Fuu-Yau Shiau

Baumann Heinz

Paras N Prasad

Compounds including a tetrapyrrolic or reduced tetrapyrrolic group/moiety and an epidermal growth factor receptor targeting group are disclosed. For example, a compound includes a tetrapyrrolic or reduced tetrapyrrolic group or moiety, a linker moiety, an epidermal growth factor receptor targeting group, and, optionally, a PET-active functional group. Uses of the compounds, for example, methods of treating a hyperproliferative tissue in an individual, and kits including one or more of the compounds are also provided.

Epidermal growth factor receptor (EGFR) targeted photosensitizers

A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.

Multifunctional nanoplatforms for fluorescence imaging and photodynamic therapy developed by post-loading photosensitizer and fluorophore to polyacrylamide nanoparticles

Provided are compositions comprising porphyrin-phospholipid nanovesicles (PoP-NVs) which can be loaded with cargo. Methods for release of cargo from the PoP-NVs triggered by near infrared (NIR) light are also disclosed.

Compositions and method for light triggered release of materials from nanovesicles

A targeting thymidine kinase photosensitizer and pharmaceutical composition and use for cancer treatment thereof is provided, which improves the selectivity of photosensitizers to tumor cells, has better tolerance, can reach maximum blood concentration in 24 hours, has a bigger conjugated system, a longer absorption wavelength and an advantage in treating depth tumors; the wavelength area does not need to consume much energy of a light-output device and even LEDs can be used, which render PDT more practical and economical. The targeting thymidine kinase photosensitizer can be used for diagnosis and for treating prostatic carcinoma via the guidance of fluorescence imaging. The pharmaceutical composition uses a combination of a chemotherapeutic agent and the targeting thymidine kinase photosensitizer, which further improves the therapeutic effect of the PDT method, expands the application range for tumors and has good effects on metastatic tumors as well.

Targeting thymidine kinase photosensitizer and pharmaceutical composition and use for cancer treatment thereof

Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver. The provided cyanine dye compound is conjugated with the photosensitizer at 2'&#x2033; position, so that tumor highly absorbs the conjugates.

Cyanine dye compound and preparation method therefor, and dual-function agent for photodynamic therapy and preparation method therefor

The invention relates to protein binding inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating cell proliferative disorders, especially cancer.

Kinase protein binding inhibitors

A compound in the form of a metallized tetrapyrollic photosensitizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emittance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.

Metallation enhancements in tumor-imaging and PDT therapy

A tetrapyrrolic photosensitizer and imaging compound having a substituent other than hydrogen at its 10 carbon atom which substituent may contain a PAA nanoparticle.

PAA nanoparticles for tumor treatment and imaging

A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.

PAA nanoplatforms containing fluorophores and targeted moieties covalently linked and photosensitizer post-loaded

Tetrapyrrolic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl6HO to oxidize the D ring and separating the resulting organic layer and drying.

B ring reduced-D ring oxidized tetrapyrrolic photosensitizers for photodynamic therapy and tumor imaging

A compound in the form of a metallized tetrpyrollic photosensizer linked to a fluorescent dye where the photosensitizer (PS), is linked by a structure that does not have detrimental radiation emmitance or absorbing characteristics, to a fluorophore, usually a cyanine dye (CD). The photosensitizer in accordance the invention is a metallized analog of porphyrins, chlorins, purpurinimides, bacterio pupurinimides, phthalocyanines, expanded porphyrins, benzoporphyrin derivatives and purpurins. The fluorophore is usually a cyanine dye with variable substituents. And, A method for determining effectiveness of PDT by comparing proportion of STAT-3 monomer with crosslinked STAT-3 dimer after PDT where the relative proportion of STAT-3 monomer to crosslinked STAT-3 directly correlates to efficacy of the PDT.

A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.

PAA nanoparticles for enhancement of tumor imaging

A method of manufacturing a lock assembly for enabling use of a key-in-knob lock cylinder assembly in different types of lock assemblies. The method includes providing a key-in-knob lock assembly having a key-in-knob housing and a plug rotatably engaged within the key-in-knob housing, providing an interchangeable core lock assembly having an interchangeable core housing, and inserting the key-in-knob housing into the interchangeable core housing such that the key-in-knob housing is universally exchangeable between the key-in-knob lock assembly and the interchangeable core lock assembly.

Lock assembly

This invention describes a first report on the synthesis of certainI-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.

Porphyrin-based compounds for tumor imaging and photodynamic therapy

Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferative tissue are provided. In another embodiment, compounds that absorb light at a wavelength of from about 700 to about 850 nm are provided. In a further embodiment, compounds that are detectable by magnetic resonance imaging are provided.

Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy

Growing community of inventors

Williamsville, NY, United States of America

Ravindra Kumar Pandey