Novartis Ag

Irm LLC

Ravinder Reddy Kondreddi

Arnab Kumar Chatterjee

Prasuna Paraselli

Advait Suresh Nagle

Jason Thomas Roland

Bin Zou

Seh Yong Leong

Robert Joseph Moreau

Wei Lin Sandra Sim

Oliver Simon

Bryan K S Yeung

Venkatataiah Bollu

Liying Jocelyn Tan

Pranab Kumar Mishra

Stefan Peukert

Pranab Mishra

Jan Jiricek

Ngai Ling Ma

Srinivasa P S Rao

Manjunatha Ujjini

Paul William Smith

Jocelyn Liying Tan

Bryan Ks Yeung

Manjunatha H Ujjini

The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by aparasite, such as malaria.

Compounds and compositions for the treatment of parasitic diseases

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of mycolic acid biosynthesis through inhibition ofEnoyl Acyl Carrier Protein Reductase enzyme (InhA): wherein R, R, R, Rand Rare as defined herein.

Pyridone derivatives and uses thereof in the treatment of tuberculosis

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: wherein R, R, R, R, Rand Rare as defined herein.

Indole carboxamide derivatives and uses thereof

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Singapore, Singapore

Ravinder Reddy Kondreddi