The General Hospital Corporation

Beth Israel Deaconess Medical Center, Inc.

The Brigham and Women's Hospital, Inc.

Harvard College

Ravi Thadhani

S Ananth Karumanchi

Anders Hayden Berg

Ishir Bhan

Thomas P Stossel

Ananth Karumanchi

Po-Shun Lee

Gavin MacBeath

Santosh Ambadas Khedkar

Alan C Rigby

Peter M Kang

Myles S Wolf

Tanya Lynn Knickerbocker

Ananth S Karumanchi

The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).

Diagnostic and therapeutic uses of gelsolin in renal failure

Described herein are assays directed to determining the level of bioavailable or free vitamin D in a blood sample in a subject. The values determined for bioavailable or free vitamin D indicate whether the subject suffers from insufficient levels of vitamin D. Also described herein are methods of treatment for vitamin D insufficiency.

Assays and methods of treatment relating to vitamin D insufficiency

The present invention relates to the discovery that an increased fraction of albumin is carbamylated in patients suffering from kidney disease (e.g., end-stage renal disease) and that the fraction of carbamylated albumin is also correlated with increased disease severity, particularly risk of mortality. The present invention also relates to the discovery that free amino acids can reduce carbamylation of albumin. Based on these discoveries the present invention provides diagnostic and prognostic methods for patients suffering from, or suspected of suffering from kidney disease. The invention also provides methods for treating kidney disease by administration of a compound or composition that reduced protein carbamylation, such as free amino acids or dipeptides.

Diagnosis, prognosis, and treatment of kidney disease

This invention features vitamin D receptor agonists, and their use in treating bone disorders, cardiovascular disease, hyperparathyroidism, immune disorders, proliferative disease, renal disease, and thrombosis.

Vitamin D receptor agonists and uses thereof

The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy.

Screening for gestational disorders

The invention relates to methods and compositions for identifying pregnant subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy, and as early as the first trimester.

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Boston, MA, United States of America

Ravi Thadhani