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Taxis Pharmaceuticals, Inc.

Ramamohan Rao Davuluri

Cadila Pharmaceuticals Limited

Davuluri Ramamohan Rao

Ravi Ponnaiah

Ajit S Parhi

Bakulesh Mafatlal Khamar

Ankur Parikh

Indravadan Ambalal Modi

Praveen Kumar Neela

Guruswamy Batthini

Anil Kumar Soni

Pullarao Seelam

Thrisulapani Korrakuti

Ajit K Parhi

Sanjeevani Ghone

Fu-An Kang

Nareshkumar Jain

Siva Rami Reddy Athunuri

Sanjay Kumar Dehury

Naresh Dongari

Santhosh Dummu

Sudhakar Sunkari

Deepthi Vpss

Savi Rami Reddy Athunuri

Dhanunjaya Naidu

Kalpesh Jadav

Swetha Mustyala

Sudheer Kallepalli

Ravi Kanth Sribhashyam

Nandkumar Mecherili Valsan

Chandra Murthy V R Medida

Prasad Chlnv

Indrajit Thakor

Selvaraju K

Srinivas Pardha Gavini Saradhi

Telagareddy Venkata Narasimharao

Kosireddy Ravanababu

Madanlal Anandkumar Lahoti

Kallepally Sudheer

Guruswamy Batthni

Selvaraju Karuppannan

Dhanunjaya S Naidu

Nandkumar Mecherill Valsan

Atul Chhotalal Joshi

Mahesh Patel

The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709:

Synthetic processes and synthetic intermediates

The present invention relates to an improved process for the preparation of Apremilast of formula (I). 

Process for the preparation of apremilast

The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709: 

The invention provides synthetic processes and synthetic intermediates that can be used to prepare a compound of formula (I): or a salt thereof.

Synthetic processes and intermediates

The invention is a novel process for the preparation of lacosamide by employing novel intermediates of formula III and IV: 

Process for the preparation of (R)-N-benzyl-2-acetamido-3-methoxypropionamide

A novel process for the preparation of 6-perdeoxy-6-per-halo Gamma cyclodextrin which is a useful intermediate in the synthesis of Sugammadex is disclosed in the invention. The process involves reacting Gamma cyclodextrin with phosphorous halide in the presence of organic solvent.

Process for preparation of Sugammadex

An improved process for the synthesis of 3-[2-[4-((6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one (Paliperidone) and Paliperidone Palmitate through a novel intermediate (2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-9-hydroxy-4H-pyrido [1,2-a]pyrimidine-4-one Palmitate ester.

Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydor-9-hydroxy-2-methyl-4H-pyrido[ 1, 2-A]-pyrimidin-4-one(paliperidone) and paliperidone palmitate

The invention provides a novel process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising of reacting the salicylic acid with salicylamide in the presence of p-toluenesulfonyl chloride, base and solvent. The use of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one in the preparation of Deferasirox is also disclosed in the invention.

Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-IH-I, 2, 4-triazolTI-yl] benzoic acid

The invention relates to a novel, industrially viable, cost effective process for the preparation of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide commonly known as Rufinamide and intermediates thereof.

Process for preparation of rufinamide

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Madurai, India

Ravi Ponnaiah