Mesoblast, Inc

Paradigm Biopharmaceuticals Ltd

Ravi Krishnan

Silviu Itescu

Paul Rennie

Peter Ghosh

Methods for the treatment of Acute Respiratory Distress Syndrome (ARDS), particularly ARDS caused by viral infections such as influenza and SARS-CoV-2, comprising the administration of pentosan polysulfate (PPS) are provided. Some provided methods comprise the administration of sodium pentosan polysulfate. Prophylactic methods comprising the administration (for example, intra-nasally) of sodium pentosan polysulfate to inactivate a vims which is causative of ARDS are also provided.

Treatment of acute respiratory disease syndrome (ARDS) with polysulfated polysaccharides

The present invention relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of disease or disorders associated with bone marrow pathologies in the musculoskeletal system of a mammal. In particular, the invention relates to use of polysulfated polysaccharides, such as pentosan polysulfate, in treatment of bone marrow edema lesions or spinal Modic Endplate Changes as assessed by magnetic resonance imaging (MRI).

Treatment of bone marrow pathologies with polysulfated polysaccharides

The present disclosure relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions. In particular, the disclosure relates to use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions mediated by mature Nerve Growth Factor (NGF) or its precursor pro-Nerve Growth Factor (pro-NGF).

Treatment of pain with polysulfated polysaccharides

The present invention relates to medical use of polysulfated polysaccharides and compositions thereof in the treatment of post-operative joint pain in a mammal. In particular, the invention relates to the use of the polysulfated polysaccharide, pentosan polysulfate, and compositions thereof in the treatment of aseptic persistent pain after joint arthroplasty in a mammal.

Treatment of post-operative joint pain with polysulfated polysaccharides

Treatment of bone marrow pathologies with polysufated polysaccharides

This application provides methods for treating a human subject suffering from a bone fracture by administering to the subject a population of cells enriched from STRO-1multipotential cells and/or multipotential progeny of such cells.

Methods for increasing osteoblastic function

The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1cells and/or progeny thereof and/or soluble factors derived therefrom.

Methods of treating or preventing respiratory conditions

The present disclosure provides methods of treating or preventing obesity or causing weight loss or treating or preventing metabolic syndrome comprising administering to a subject a population of cells enriched for STRO-1cells and/or progeny thereof and/or soluble factors derived therefrom.

Methods for treating obesity and/or metabolic syndrome

The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1cells and/or progeny cells thereof and/or soluble factors derived therefrom. The method of the invention is useful for treating and/or preventing and/or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.

Method for treating or preventing a pancreatic dysfunction

The present disclosure provides methods of increasing osteoblastic function in a subject, the method comprising systemically administering to the subject a population of stem cells and/or progeny thereof and/or soluble factors derived therefrom.

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Royston Park, Australia

Ravi Krishnan